home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 273.5 KB |
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MacOS 8.1
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Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000490| 00 00 39 35 00 00 00 01 | d7 fe 03 00 c9 0c 00 00 |..95....|........|
|000004a0| 39 36 00 00 00 01 a0 0b | 04 00 3c 0c 00 00 39 37 |96......|..<...97|
|000004b0| 00 00 00 01 dc 17 04 00 | 15 12 00 00 39 38 00 00 |........|....98..|
|000004c0| 00 01 f1 29 04 00 91 0f | 00 00 39 39 00 00 00 01 |...)....|..99....|
|000004d0| 82 39 04 00 4e 0c 00 00 | 00 00 00 00 00 00 d0 45 |.9..N...|.......E|
|000004e0| 04 00 00 00 00 00 24 55 | 6e 69 71 75 65 5f 49 44 |......$U|nique_ID|
|000004f0| 7b 59 52 42 31 30 31 30 | 30 7d 0d 0a 24 54 69 74 |{YRB1010|0}..$Tit|
|00000500| 6c 65 7b 42 6f 74 75 6c | 69 6e 75 6d 20 54 6f 78 |le{Botul|inum Tox|
|00000510| 69 6e 20 49 6e 6a 65 63 | 74 69 6f 6e 73 20 69 6e |in Injec|tions in|
|00000520| 20 74 68 65 20 54 72 65 | 61 74 6d 65 6e 74 20 6f | the Tre|atment o|
|00000530| 66 20 42 6c 65 70 68 61 | 72 6f 73 70 61 73 6d 2c |f Blepha|rospasm,|
|00000540| 20 48 65 6d 69 66 61 63 | 69 61 6c 20 53 70 61 73 | Hemifac|ial Spas|
|00000550| 6d 2c 20 61 6e 64 20 45 | 79 65 6c 69 64 20 46 61 |m, and E|yelid Fa|
|00000560| 73 63 69 63 75 6c 61 74 | 69 6f 6e 73 7d 0d 0a 24 |sciculat|ions}..$|
|00000570| 41 75 74 68 6f 72 7b 4b | 72 61 66 74 2c 20 53 50 |Author{K|raft, SP|
|00000580| 0d 0a 4c 61 6e 67 2c 20 | 41 45 7d 0d 0a 24 41 66 |..Lang, |AE}..$Af|
|00000590| 66 69 6c 69 61 74 69 6f | 6e 7b 55 6e 69 76 20 6f |filiatio|n{Univ o|
|000005a0| 66 20 54 6f 72 6f 6e 74 | 6f 3b 20 54 6f 72 6f 6e |f Toront|o; Toron|
|000005b0| 74 6f 20 57 65 73 74 65 | 72 6e 20 48 6f 73 70 7d |to Weste|rn Hosp}|
|000005c0| 0d 0a 24 4a 6f 75 72 6e | 61 6c 7b 43 61 6e 20 4a |..$Journ|al{Can J|
|000005d0| 20 4e 65 75 72 6f 6c 20 | 53 63 69 7d 0d 0a 24 56 | Neurol |Sci}..$V|
|000005e0| 6f 6c 75 6d 65 7b 31 35 | 7d 0d 0a 24 50 61 67 65 |olume{15|}..$Page|
|000005f0| 7b 32 37 36 2d 32 38 30 | 7d 0d 0a 24 44 61 74 65 |{276-280|}..$Date|
|00000600| 7b 41 75 67 75 73 74 20 | 31 39 38 38 7d 0d 0a 24 |{August |1988}..$|
|00000610| 59 42 56 6f 6c 7b 31 39 | 39 30 20 59 65 61 72 20 |YBVol{19|90 Year |
|00000620| 42 6f 6f 6b 20 6f 66 20 | 44 72 75 67 20 54 68 65 |Book of |Drug The|
|00000630| 72 61 70 79 7d 0d 0a 24 | 43 68 61 70 74 65 72 7b |rapy}..$|Chapter{|
|00000640| 31 36 2d 32 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |16-2}..$|YBEditor|
|00000650| 7b 44 72 73 2e 20 48 6f | 6c 6c 69 73 74 65 72 20 |{Drs. Ho|llister |
|00000660| 61 6e 64 20 4c 61 73 61 | 67 6e 61 7d 0d 0a 24 54 |and Lasa|gna}..$T|
|00000670| 61 62 6c 65 7b 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |able{}..|$Comment|
|00000680| 61 74 6f 72 7b 4c 2e 20 | 20 4c 61 73 61 67 6e 61 |ator{L. | Lasagna|
|00000690| 2c 20 4d 2e 44 2e 7d 0d | 0a 0d 0a 43 6f 70 79 72 |, M.D.}.|...Copyr|
|000006a0| 69 67 68 74 20 28 63 29 | 20 59 65 61 72 62 6f 6f |ight (c)| Yearboo|
|000006b0| 6b 20 4d 65 64 69 63 61 | 6c 20 50 75 62 6c 69 73 |k Medica|l Publis|
|000006c0| 68 65 72 73 2c 20 49 6e | 63 2e 2c 20 31 39 39 30 |hers, In|c., 1990|
|000006d0| 0d 0a 0d 0a 31 39 39 30 | 20 59 65 61 72 20 42 6f |....1990| Year Bo|
|000006e0| 6f 6b 20 6f 66 20 44 72 | 75 67 20 54 68 65 72 61 |ok of Dr|ug Thera|
|000006f0| 70 79 20 28 52 29 0d 0a | 0d 0a 43 68 61 70 74 65 |py (R)..|..Chapte|
|00000700| 72 20 31 36 2d 2d 45 79 | 65 2c 20 45 61 72 2c 20 |r 16--Ey|e, Ear, |
|00000710| 4e 6f 73 65 2c 20 61 6e | 64 20 54 68 72 6f 61 74 |Nose, an|d Throat|
|00000720| 0d 0a 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |....----|--------|
|00000730| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000740| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000750| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000760| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000770| 2d 2d 0d 0a 42 6f 74 75 | 6c 69 6e 75 6d 20 54 6f |--..Botu|linum To|
|00000780| 78 69 6e 20 49 6e 6a 65 | 63 74 69 6f 6e 73 20 69 |xin Inje|ctions i|
|00000790| 6e 20 74 68 65 20 54 72 | 65 61 74 6d 65 6e 74 20 |n the Tr|eatment |
|000007a0| 6f 66 20 42 6c 65 70 68 | 61 72 6f 73 70 61 73 6d |of Bleph|arospasm|
|000007b0| 2c 20 48 65 6d 69 66 61 | 63 69 61 6c 0d 0a 53 70 |, Hemifa|cial..Sp|
|000007c0| 61 73 6d 2c 20 61 6e 64 | 20 45 79 65 6c 69 64 20 |asm, and| Eyelid |
|000007d0| 46 61 73 63 69 63 75 6c | 61 74 69 6f 6e 73 0d 0a |Fascicul|ations..|
|000007e0| 0d 0a 4b 72 61 66 74 20 | 53 50 3b 20 4c 61 6e 67 |..Kraft |SP; Lang|
|000007f0| 20 41 45 0d 0a 28 55 6e | 69 76 20 6f 66 20 54 6f | AE..(Un|iv of To|
|00000800| 72 6f 6e 74 6f 3b 20 54 | 6f 72 6f 6e 74 6f 20 57 |ronto; T|oronto W|
|00000810| 65 73 74 65 72 6e 20 48 | 6f 73 70 29 0d 0a 43 61 |estern H|osp)..Ca|
|00000820| 6e 20 4a 20 4e 65 75 72 | 6f 6c 20 53 63 69 20 31 |n J Neur|ol Sci 1|
|00000830| 35 3a 32 37 36 2d 32 38 | 30 2c 20 41 75 67 75 73 |5:276-28|0, Augus|
|00000840| 74 20 31 39 38 38 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |t 1988..|--------|
|00000850| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000860| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000870| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000880| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000890| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
|000008a0| 63 74 0d 0a 0d 0a 20 20 | 20 20 20 42 6f 74 75 6c |ct.... | Botul|
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|000009f0| 6e 6a 65 63 74 69 6f 6e | 73 20 66 6f 72 20 68 65 |njection|s for he|
|00000a00| 6d 69 66 61 63 69 61 6c | 20 73 70 61 73 6d 3b 20 |mifacial| spasm; |
|00000a10| 61 6e 64 20 33 20 70 61 | 74 69 65 6e 74 73 20 61 |and 3 pa|tients a|
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|00000a70| 0d 0a 66 61 73 63 69 63 | 75 6c 61 74 69 6f 6e 73 |..fascic|ulations|
|00000a80| 2e 0d 0a 20 20 20 20 20 | 54 6f 74 61 6c 20 72 65 |... |Total re|
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|00000b10| 6c 20 73 70 61 73 6d 2e | 0d 0a 42 65 63 61 75 73 |l spasm.|..Becaus|
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|00000b30| 79 20 74 65 6d 70 6f 72 | 61 72 79 2c 20 68 6f 77 |y tempor|ary, how|
|00000b40| 65 76 65 72 2c 20 74 72 | 65 61 74 6d 65 6e 74 73 |ever, tr|eatments|
|00000b50| 20 68 61 64 20 74 6f 20 | 62 65 20 72 65 70 65 61 | had to |be repea|
|00000b60| 74 65 64 20 61 74 0d 0a | 72 65 67 75 6c 61 72 20 |ted at..|regular |
|00000b70| 69 6e 74 65 72 76 61 6c | 73 2e 20 20 50 61 74 69 |interval|s. Pati|
|00000b80| 65 6e 74 73 20 77 69 74 | 68 20 73 65 76 65 72 65 |ents wit|h severe|
|00000b90| 20 73 79 6d 70 74 6f 6d | 73 20 68 61 64 20 61 20 | symptom|s had a |
|00000ba0| 73 68 6f 72 74 65 72 20 | 64 75 72 61 74 69 6f 6e |shorter |duration|
|00000bb0| 20 6f 66 0d 0a 72 65 6c | 69 65 66 20 74 68 61 6e | of..rel|ief than|
|00000bc0| 20 64 69 64 20 74 68 6f | 73 65 20 77 69 74 68 20 | did tho|se with |
|00000bd0| 6d 69 6c 64 65 72 20 73 | 79 6d 70 74 6f 6d 73 2e |milder s|ymptoms.|
|00000be0| 20 20 54 68 65 20 33 20 | 70 61 74 69 65 6e 74 73 | The 3 |patients|
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|00000c00| 6c 69 64 0d 0a 66 61 73 | 63 69 63 75 6c 61 74 69 |lid..fas|ciculati|
|00000c10| 6f 6e 73 20 72 65 6d 61 | 69 6e 65 64 20 73 79 6d |ons rema|ined sym|
|00000c20| 70 74 6f 6d 20 66 72 65 | 65 20 66 6f 72 20 61 74 |ptom fre|e for at|
|00000c30| 20 6c 65 61 73 74 20 36 | 30 2d 38 30 20 77 65 65 | least 6|0-80 wee|
|00000c40| 6b 73 20 61 66 74 65 72 | 20 61 20 73 69 6e 67 6c |ks after| a singl|
|00000c50| 65 0d 0a 74 72 65 61 74 | 6d 65 6e 74 2e 20 20 54 |e..treat|ment. T|
|00000c60| 68 65 72 65 20 77 65 72 | 65 20 6e 6f 20 73 79 73 |here wer|e no sys|
|00000c70| 74 65 6d 69 63 20 72 65 | 61 63 74 69 6f 6e 73 20 |temic re|actions |
|00000c80| 74 6f 20 74 68 65 20 69 | 6e 6a 65 63 74 69 6f 6e |to the i|njection|
|00000c90| 73 2e 20 20 54 72 61 6e | 73 69 65 6e 74 0d 0a 73 |s. Tran|sient..s|
|00000ca0| 69 64 65 20 65 66 66 65 | 63 74 73 20 69 6e 63 6c |ide effe|cts incl|
|00000cb0| 75 64 65 64 20 70 74 6f | 73 69 73 20 69 6e 20 32 |uded pto|sis in 2|
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|00000cd0| 31 38 25 2c 20 74 65 61 | 72 69 6e 67 20 69 6e 20 |18%, tea|ring in |
|00000ce0| 35 2e 35 25 2c 20 61 6e | 64 0d 0a 73 74 72 61 62 |5.5%, an|d..strab|
|00000cf0| 69 73 6d 75 73 20 69 6e | 20 31 2e 34 25 2e 0d 0a |ismus in| 1.4%...|
|00000d00| 20 20 20 20 20 42 6f 74 | 75 6c 69 6e 75 6d 20 74 | Bot|ulinum t|
|00000d10| 6f 78 69 6e 20 69 6e 6a | 65 63 74 69 6f 6e 20 69 |oxin inj|ection i|
|00000d20| 73 20 68 69 67 68 6c 79 | 20 65 66 66 65 63 74 69 |s highly| effecti|
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|00000d40| 65 6e 74 20 6f 66 0d 0a | 62 6c 65 70 68 61 72 6f |ent of..|blepharo|
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|00002170| 76 6f 62 75 6e 6f 6c 6f | 6c 20 77 69 74 68 0d 0a |vobunolo|l with..|
|00002180| 64 69 70 69 76 65 66 72 | 69 6e 20 77 65 72 65 20 |dipivefr|in were |
|00002190| 73 69 6d 69 6c 61 72 20 | 74 6f 20 74 68 61 74 20 |similar |to that |
|000021a0| 6f 66 20 74 69 6d 6f 6c | 6f 6c 20 63 6f 6d 62 69 |of timol|ol combi|
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|00002220| 0a 0d 0a 50 6f 73 74 2d | 43 6f 6d 6d 65 6e 74 0d |...Post-|Comment.|
|00002230| 0a 0d 0a 20 20 20 20 20 | 4c 65 76 6f 62 75 6e 6f |... |Levobuno|
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|00002250| 65 74 61 31 2d 20 61 6e | 64 20 62 65 74 61 32 2d |eta1- an|d beta2-|
|00002260| 61 64 72 65 6e 6f 72 65 | 63 65 70 74 6f 72 20 61 |adrenore|ceptor a|
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|00002280| 77 68 61 74 20 61 6e 61 | 6c 6f 67 6f 75 73 20 74 |what ana|logous t|
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|000022a0| 76 65 66 72 69 6e 20 69 | 73 20 65 73 73 65 6e 74 |vefrin i|s essent|
|000022b0| 69 61 6c 6c 79 20 61 20 | 6c 6f 6e 67 2d 61 63 74 |ially a |long-act|
|000022c0| 69 6e 67 0d 0a 65 70 69 | 6e 65 70 68 72 69 6e 65 |ing..epi|nephrine|
|000022d0| 2e 20 20 54 68 69 73 20 | 63 6f 6d 62 69 6e 61 74 |. This |combinat|
|000022e0| 69 6f 6e 20 77 61 73 20 | 65 71 75 69 76 61 6c 65 |ion was |equivale|
|000022f0| 6e 74 20 66 6f 72 20 72 | 65 64 75 63 69 6e 67 20 |nt for r|educing |
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|00002310| 73 73 75 72 65 20 69 6e | 20 70 61 74 69 65 6e 74 |ssure in| patient|
|00002320| 73 20 77 69 74 68 20 67 | 6c 61 75 63 6f 6d 61 20 |s with g|laucoma |
|00002330| 61 73 20 77 61 73 20 61 | 20 63 6f 6d 62 69 6e 61 |as was a| combina|
|00002340| 74 69 6f 6e 20 6f 66 20 | 74 69 6d 6f 6c 6f 6c 20 |tion of |timolol |
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|00002360| 20 20 55 6e 6c 65 73 73 | 20 73 6f 6d 65 20 61 64 | Unless| some ad|
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|000023b0| 45 2e 20 48 6f 6c 6c 69 | 73 74 65 72 2c 20 4d 2e |E. Holli|ster, M.|
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|000024b0| 50 61 67 65 7b 36 37 31 | 2d 36 37 35 7d 0d 0a 24 |Page{671|-675}..$|
|000024c0| 44 61 74 65 7b 4a 75 6e | 65 20 31 39 38 38 7d 0d |Date{Jun|e 1988}.|
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|00002610| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002620| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002630| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 54 72 65 61 74 6d 65 |-------.|.Treatme|
|00002640| 6e 74 20 6f 66 20 53 65 | 76 65 72 65 20 52 65 63 |nt of Se|vere Rec|
|00002650| 75 72 72 65 6e 74 20 41 | 70 68 74 68 6f 75 73 20 |urrent A|phthous |
|00002660| 53 74 6f 6d 61 74 69 74 | 69 73 20 57 69 74 68 20 |Stomatit|is With |
|00002670| 43 6f 6c 63 68 69 63 69 | 6e 65 0d 0a 0d 0a 52 75 |Colchici|ne....Ru|
|00002680| 61 68 20 43 42 3b 20 53 | 74 72 61 6d 20 4a 52 3b |ah CB; S|tram JR;|
|00002690| 20 43 68 61 73 69 6e 20 | 57 44 0d 0a 28 54 75 66 | Chasin |WD..(Tuf|
|000026a0| 74 73 20 55 6e 69 76 3b | 20 42 6f 73 74 6f 6e 20 |ts Univ;| Boston |
|000026b0| 55 6e 69 76 29 0d 0a 41 | 72 63 68 20 4f 74 6f 6c |Univ)..A|rch Otol|
|000026c0| 61 72 79 6e 67 6f 6c 20 | 48 65 61 64 20 4e 65 63 |aryngol |Head Nec|
|000026d0| 6b 20 53 75 72 67 20 31 | 31 34 3a 36 37 31 2d 36 |k Surg 1|14:671-6|
|000026e0| 37 35 2c 20 4a 75 6e 65 | 20 31 39 38 38 0d 0a 2d |75, June| 1988..-|
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|00002710| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002720| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002730| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 0d |--------|-----...|
|00002740| 0a 41 62 73 74 72 61 63 | 74 0d 0a 0d 0a 20 20 20 |.Abstrac|t.... |
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|00002850| 53 79 6d 70 74 6f 6d 73 | 20 64 65 63 72 65 61 73 |Symptoms| decreas|
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|00002aa0| 63 75 72 72 65 6e 74 20 | 61 70 68 74 68 6f 75 73 |current |aphthous|
|00002ab0| 20 73 74 6f 6d 61 74 69 | 74 69 73 20 69 73 20 61 | stomati|tis is a|
|00002ac0| 73 0d 0a 66 6f 6c 6c 6f | 77 73 3a 20 20 64 65 70 |s..follo|ws: dep|
|00002ad0| 6f 73 69 74 69 6f 6e 20 | 6f 66 20 69 6d 6d 75 6e |osition |of immun|
|00002ae0| 65 20 63 6f 6d 70 6c 65 | 78 65 73 20 69 6e 20 74 |e comple|xes in t|
|00002af0| 68 65 20 6f 72 61 6c 20 | 6d 75 63 6f 73 61 20 73 |he oral |mucosa s|
|00002b00| 74 69 6d 75 6c 61 74 65 | 73 0d 0a 69 6e 66 6c 61 |timulate|s..infla|
|00002b10| 6d 6d 61 74 6f 72 79 20 | 63 65 6c 6c 20 69 6e 66 |mmatory |cell inf|
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|00002b70| 20 64 65 70 6f 6c 79 6d | 65 72 69 7a 65 73 20 6d | depolym|erizes m|
|00002b80| 69 63 72 6f 74 75 62 75 | 6c 61 72 20 70 72 6f 74 |icrotubu|lar prot|
|00002b90| 65 69 6e 73 20 6f 66 20 | 74 68 65 73 65 0d 0a 69 |eins of |these..i|
|00002ba0| 6e 66 6c 61 6d 6d 61 74 | 6f 72 79 20 63 65 6c 6c |nflammat|ory cell|
|00002bb0| 73 2e 20 20 43 6f 6c 63 | 68 69 63 69 6e 65 20 68 |s. Colc|hicine h|
|00002bc0| 61 73 20 62 65 65 6e 20 | 75 73 65 64 20 77 69 74 |as been |used wit|
|00002bd0| 68 20 73 75 63 63 65 73 | 73 20 69 6e 20 74 68 65 |h succes|s in the|
|00002be0| 20 70 61 73 74 20 74 6f | 0d 0a 74 72 65 61 74 20 | past to|..treat |
|00002bf0| 42 65 68 63 65 74 27 73 | 20 64 69 73 65 61 73 65 |Behcet's| disease|
|00002c00| 2c 20 77 68 69 63 68 20 | 69 73 20 61 6c 73 6f 20 |, which |is also |
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|00002c20| 20 6f 72 61 6c 20 75 6c | 63 65 72 73 2e 20 20 54 | oral ul|cers. T|
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|00002c40| 68 65 20 33 20 70 61 74 | 69 65 6e 74 73 20 72 65 |he 3 pat|ients re|
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|00002ce0| 65 6c 70 2e 2d 2d 4c 2e | 45 2e 20 48 6f 6c 6c 69 |elp.--L.|E. Holli|
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|00002e90| 74 6f 72 7b 4c 2e 20 20 | 4c 61 73 61 67 6e 61 2c |tor{L. |Lasagna,|
|00002ea0| 20 4d 2e 44 2e 7d 0d 0a | 0d 0a 43 6f 70 79 72 69 | M.D.}..|..Copyri|
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|00002ed0| 65 72 73 2c 20 49 6e 63 | 2e 2c 20 31 39 39 30 0d |ers, Inc|., 1990.|
|00002ee0| 0a 0d 0a 31 39 39 30 20 | 59 65 61 72 20 42 6f 6f |...1990 |Year Boo|
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|00002f00| 79 20 28 52 29 0d 0a 0d | 0a 43 68 61 70 74 65 72 |y (R)...|.Chapter|
|00002f10| 20 31 37 2d 2d 52 65 73 | 70 69 72 61 74 6f 72 79 | 17--Res|piratory|
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|00002f30| 0d 0a 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |....----|--------|
|00002f40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002f50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002f60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002f70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002f80| 2d 2d 0d 0a 4f 72 61 6c | 20 54 65 72 62 75 74 61 |--..Oral| Terbuta|
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|00002fd0| 72 79 0d 0a 44 69 73 65 | 61 73 65 0d 0a 0d 0a 43 |ry..Dise|ase....C|
|00002fe0| 68 61 6e 20 43 4b 3b 20 | 4c 6f 6b 65 20 4a 3b 20 |han CK; |Loke J; |
|00002ff0| 53 6e 79 64 65 72 20 50 | 45 3b 20 57 61 63 6b 65 |Snyder P|E; Wacke|
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|00003010| 20 4d 61 74 74 68 61 79 | 20 52 41 0d 0a 28 59 61 | Matthay| RA..(Ya|
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|00003030| 65 64 20 53 63 69 20 32 | 39 36 3a 33 33 2d 33 38 |ed Sci 2|96:33-38|
|00003040| 2c 20 4a 75 6c 79 20 31 | 39 38 38 0d 0a 2d 2d 2d |, July 1|988..---|
|00003050| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003060| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003070| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003080| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003090| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 0d 0a 41 |--------|---....A|
|000030a0| 62 73 74 72 61 63 74 0d | 0a 0d 0a 20 20 20 20 20 |bstract.|... |
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|00003a50| 72 7b 4c 2e 45 2e 20 48 | 6f 6c 6c 69 73 74 65 72 |r{L.E. H|ollister|
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|00003ae0| 79 20 54 72 61 63 74 20 | 44 69 73 6f 72 64 65 72 |y Tract |Disorder|
|00003af0| 73 0d 0a 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |s....---|--------|
|00003b00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003b10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003b20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003b30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003b40| 2d 2d 2d 0d 0a 53 65 72 | 69 6f 75 73 20 49 6e 66 |---..Ser|ious Inf|
|00003b50| 65 63 74 69 6f 75 73 20 | 43 6f 6d 70 6c 69 63 61 |ectious |Complica|
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|00003b80| 66 6f 72 20 43 4f 50 44 | 0d 0a 0d 0a 57 69 65 73 |for COPD|....Wies|
|00003b90| 74 20 50 4d 3b 20 46 6c | 61 6e 69 67 61 6e 20 54 |t PM; Fl|anigan T|
|00003ba0| 3b 20 53 61 6c 61 74 61 | 20 52 41 3b 20 53 68 6c |; Salata| RA; Shl|
|00003bb0| 61 65 73 20 44 4d 3b 20 | 4b 61 74 7a 6d 61 6e 20 |aes DM; |Katzman |
|00003bc0| 4d 3b 20 4c 65 64 65 72 | 6d 61 6e 20 4d 4d 0d 0a |M; Leder|man MM..|
|00003bd0| 28 55 6e 69 76 20 48 6f | 73 70 73 20 6f 66 20 43 |(Univ Ho|sps of C|
|00003be0| 6c 65 76 65 6c 61 6e 64 | 3b 20 57 61 64 65 20 50 |leveland|; Wade P|
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|00003c00| 43 6c 65 76 65 6c 61 6e | 64 29 0d 0a 43 68 65 73 |Clevelan|d)..Ches|
|00003c10| 74 20 39 35 3a 31 31 38 | 30 2d 31 31 38 34 2c 20 |t 95:118|0-1184, |
|00003c20| 4a 75 6e 65 20 31 39 38 | 39 0d 0a 2d 2d 2d 2d 2d |June 198|9..-----|
|00003c30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003c40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003c50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003c60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003c70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 0d 0a 41 62 73 |--------|-....Abs|
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|00003e70| 0a 66 6f 72 20 35 2d 36 | 33 20 64 61 79 73 2e 20 |.for 5-6|3 days. |
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|00004080| 20 54 68 65 20 62 65 6e | 65 66 69 74 73 20 6f 66 | The ben|efits of|
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|000040c0| 6c 6f 6e 67 65 72 0d 0a | 64 75 72 61 74 69 6f 6e |longer..|duration|
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|00004140| 0d 0a 0d 0a 50 6f 73 74 | 2d 43 6f 6d 6d 65 6e 74 |....Post|-Comment|
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|00004200| 72 79 20 64 69 73 65 61 | 73 65 20 6d 69 67 68 74 |ry disea|se might|
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|00004240| 20 63 6f 6d 70 6c 69 63 | 61 74 69 6f 6e 73 2e 20 | complic|ations. |
|00004250| 20 54 68 65 20 37 20 70 | 61 74 69 65 6e 74 73 20 | The 7 p|atients |
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|000042d0| 74 65 72 6f 69 64 73 20 | 69 6e 20 74 68 65 20 6c |teroids |in the l|
|000042e0| 6f 6e 67 2d 74 65 72 6d | 20 6d 61 6e 61 67 65 6d |ong-term| managem|
|000042f0| 65 6e 74 20 6f 66 20 43 | 4f 50 44 2c 20 63 6f 6e |ent of C|OPD, con|
|00004300| 74 69 6e 75 65 64 20 68 | 69 67 68 2d 64 6f 73 65 |tinued h|igh-dose|
|00004310| 0d 0a 74 72 65 61 74 6d | 65 6e 74 20 64 6f 65 73 |..treatm|ent does|
|00004320| 20 6e 6f 74 20 73 65 65 | 6d 20 74 6f 20 62 65 20 | not see|m to be |
|00004330| 74 68 65 20 77 61 79 20 | 74 6f 20 67 6f 2e 20 20 |the way |to go. |
|00004340| 52 61 74 68 65 72 2c 20 | 74 72 65 61 74 6d 65 6e |Rather, |treatmen|
|00004350| 74 20 6d 69 67 68 74 20 | 62 65 0d 0a 69 6e 74 65 |t might |be..inte|
|00004360| 72 6d 69 74 74 65 6e 74 | 2c 20 6f 72 20 69 66 20 |rmittent|, or if |
|00004370| 63 6f 6e 74 69 6e 75 65 | 64 2c 20 6c 6f 77 65 72 |continue|d, lower|
|00004380| 20 64 6f 73 65 73 20 73 | 68 6f 75 6c 64 20 62 65 | doses s|hould be|
|00004390| 20 75 73 65 64 2e 2d 2d | 4c 2e 45 2e 20 48 6f 6c | used.--|L.E. Hol|
|000043a0| 6c 69 73 74 65 72 2c 0d | 0a 4d 2e 44 2e 0d 0a 24 |lister,.|.M.D...$|
|000043b0| 55 6e 69 71 75 65 5f 49 | 44 7b 59 52 42 31 30 31 |Unique_I|D{YRB101|
|000043c0| 30 36 7d 0d 0a 24 54 69 | 74 6c 65 7b 45 66 66 65 |06}..$Ti|tle{Effe|
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|00004400| 69 73 65 20 54 6f 6c 65 | 72 61 6e 63 65 20 69 6e |ise Tole|rance in|
|00004410| 0d 0a 50 61 74 69 65 6e | 74 73 20 57 69 74 68 20 |..Patien|ts With |
|00004420| 43 68 72 6f 6e 69 63 20 | 4f 62 73 74 72 75 63 74 |Chronic |Obstruct|
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|00004450| 4c 69 67 68 74 2c 20 52 | 57 0d 0a 4d 75 72 6f 2c |Light, R|W..Muro,|
|00004460| 20 4a 52 0d 0a 53 61 74 | 6f 2c 20 52 49 0d 0a 53 | JR..Sat|o, RI..S|
|00004470| 74 61 6e 73 62 75 72 79 | 2c 20 44 57 0d 0a 46 69 |tansbury|, DW..Fi|
|00004480| 73 63 68 65 72 2c 20 43 | 45 0d 0a 42 72 6f 77 6e |scher, C|E..Brown|
|00004490| 2c 20 53 45 7d 0d 0a 24 | 41 66 66 69 6c 69 61 74 |, SE}..$|Affiliat|
|000044a0| 69 6f 6e 7b 56 41 20 4d | 65 64 20 43 74 72 2c 20 |ion{VA M|ed Ctr, |
|000044b0| 4c 6f 6e 67 20 42 65 61 | 63 68 2c 20 43 61 6c 69 |Long Bea|ch, Cali|
|000044c0| 66 3b 20 55 6e 69 76 20 | 6f 66 20 43 61 6c 69 66 |f; Univ |of Calif|
|000044d0| 6f 72 6e 69 61 2c 20 49 | 72 76 69 6e 65 7d 0d 0a |ornia, I|rvine}..|
|000044e0| 24 4a 6f 75 72 6e 61 6c | 7b 41 6d 20 52 65 76 20 |$Journal|{Am Rev |
|000044f0| 52 65 73 70 69 72 20 44 | 69 73 7d 0d 0a 24 56 6f |Respir D|is}..$Vo|
|00004500| 6c 75 6d 65 7b 31 33 39 | 7d 0d 0a 24 50 61 67 65 |lume{139|}..$Page|
|00004510| 7b 31 32 36 2d 31 33 33 | 7d 0d 0a 24 44 61 74 65 |{126-133|}..$Date|
|00004520| 7b 4a 61 6e 75 61 72 79 | 20 31 39 38 39 7d 0d 0a |{January| 1989}..|
|00004530| 24 59 42 56 6f 6c 7b 31 | 39 39 30 20 59 65 61 72 |$YBVol{1|990 Year|
|00004540| 20 42 6f 6f 6b 20 6f 66 | 20 44 72 75 67 20 54 68 | Book of| Drug Th|
|00004550| 65 72 61 70 79 7d 0d 0a | 24 43 68 61 70 74 65 72 |erapy}..|$Chapter|
|00004560| 7b 31 37 2d 33 7d 0d 0a | 24 59 42 45 64 69 74 6f |{17-3}..|$YBEdito|
|00004570| 72 7b 44 72 73 2e 20 48 | 6f 6c 6c 69 73 74 65 72 |r{Drs. H|ollister|
|00004580| 20 61 6e 64 20 4c 61 73 | 61 67 6e 61 7d 0d 0a 24 | and Las|agna}..$|
|00004590| 54 61 62 6c 65 7b 7d 0d | 0a 24 43 6f 6d 6d 65 6e |Table{}.|.$Commen|
|000045a0| 74 61 74 6f 72 7b 4c 2e | 20 20 4c 61 73 61 67 6e |tator{L.| Lasagn|
|000045b0| 61 2c 20 4d 2e 44 2e 7d | 0d 0a 0d 0a 43 6f 70 79 |a, M.D.}|....Copy|
|000045c0| 72 69 67 68 74 20 28 63 | 29 20 59 65 61 72 62 6f |right (c|) Yearbo|
|000045d0| 6f 6b 20 4d 65 64 69 63 | 61 6c 20 50 75 62 6c 69 |ok Medic|al Publi|
|000045e0| 73 68 65 72 73 2c 20 49 | 6e 63 2e 2c 20 31 39 39 |shers, I|nc., 199|
|000045f0| 30 0d 0a 0d 0a 31 39 39 | 30 20 59 65 61 72 20 42 |0....199|0 Year B|
|00004600| 6f 6f 6b 20 6f 66 20 44 | 72 75 67 20 54 68 65 72 |ook of D|rug Ther|
|00004610| 61 70 79 20 28 52 29 0d | 0a 0d 0a 43 68 61 70 74 |apy (R).|...Chapt|
|00004620| 65 72 20 31 37 2d 2d 52 | 65 73 70 69 72 61 74 6f |er 17--R|espirato|
|00004630| 72 79 20 54 72 61 63 74 | 20 44 69 73 6f 72 64 65 |ry Tract| Disorde|
|00004640| 72 73 0d 0a 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |rs....--|--------|
|00004650| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004660| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004670| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004680| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004690| 2d 2d 2d 2d 0d 0a 45 66 | 66 65 63 74 73 20 6f 66 |----..Ef|fects of|
|000046a0| 20 4f 72 61 6c 20 4d 6f | 72 70 68 69 6e 65 20 6f | Oral Mo|rphine o|
|000046b0| 6e 20 42 72 65 61 74 68 | 6c 65 73 73 6e 65 73 73 |n Breath|lessness|
|000046c0| 20 61 6e 64 20 45 78 65 | 72 63 69 73 65 20 54 6f | and Exe|rcise To|
|000046d0| 6c 65 72 61 6e 63 65 20 | 69 6e 20 50 61 74 69 65 |lerance |in Patie|
|000046e0| 6e 74 73 0d 0a 57 69 74 | 68 20 43 68 72 6f 6e 69 |nts..Wit|h Chroni|
|000046f0| 63 20 4f 62 73 74 72 75 | 63 74 69 76 65 20 50 75 |c Obstru|ctive Pu|
|00004700| 6c 6d 6f 6e 61 72 79 20 | 44 69 73 65 61 73 65 0d |lmonary |Disease.|
|00004710| 0a 0d 0a 4c 69 67 68 74 | 20 52 57 3b 20 4d 75 72 |...Light| RW; Mur|
|00004720| 6f 20 4a 52 3b 20 53 61 | 74 6f 20 52 49 3b 20 53 |o JR; Sa|to RI; S|
|00004730| 74 61 6e 73 62 75 72 79 | 20 44 57 3b 20 46 69 73 |tansbury| DW; Fis|
|00004740| 63 68 65 72 20 43 45 3b | 20 42 72 6f 77 6e 20 53 |cher CE;| Brown S|
|00004750| 45 0d 0a 28 56 41 20 4d | 65 64 20 43 74 72 2c 20 |E..(VA M|ed Ctr, |
|00004760| 4c 6f 6e 67 20 42 65 61 | 63 68 2c 20 43 61 6c 69 |Long Bea|ch, Cali|
|00004770| 66 3b 20 55 6e 69 76 20 | 6f 66 20 43 61 6c 69 66 |f; Univ |of Calif|
|00004780| 6f 72 6e 69 61 2c 20 49 | 72 76 69 6e 65 29 0d 0a |ornia, I|rvine)..|
|00004790| 41 6d 20 52 65 76 20 52 | 65 73 70 69 72 20 44 69 |Am Rev R|espir Di|
|000047a0| 73 20 31 33 39 3a 31 32 | 36 2d 31 33 33 2c 20 4a |s 139:12|6-133, J|
|000047b0| 61 6e 75 61 72 79 20 31 | 39 38 39 0d 0a 2d 2d 2d |anuary 1|989..---|
|000047c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000047d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000047e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000047f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004800| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 0d 0a 41 |--------|---....A|
|00004810| 62 73 74 72 61 63 74 0d | 0a 0d 0a 20 20 20 20 20 |bstract.|... |
|00004820| 41 64 6d 69 6e 69 73 74 | 72 61 74 69 6f 6e 20 6f |Administ|ration o|
|00004830| 66 20 6f 70 69 61 74 65 | 73 20 69 6e 63 72 65 61 |f opiate|s increa|
|00004840| 73 65 73 20 74 68 65 20 | 65 78 65 72 63 69 73 65 |ses the |exercise|
|00004850| 20 74 6f 6c 65 72 61 6e | 63 65 20 6f 66 20 70 61 | toleran|ce of pa|
|00004860| 74 69 65 6e 74 73 0d 0a | 77 69 74 68 20 63 68 72 |tients..|with chr|
|00004870| 6f 6e 69 63 20 6f 62 73 | 74 72 75 63 74 69 76 65 |onic obs|tructive|
|00004880| 20 70 75 6c 6d 6f 6e 61 | 72 79 20 64 69 73 65 61 | pulmona|ry disea|
|00004890| 73 65 20 28 43 4f 50 44 | 29 2c 20 62 75 74 20 74 |se (COPD|), but t|
|000048a0| 68 65 20 6d 65 63 68 61 | 6e 69 73 6d 0d 0a 72 65 |he mecha|nism..re|
|000048b0| 73 70 6f 6e 73 69 62 6c | 65 20 66 6f 72 20 74 68 |sponsibl|e for th|
|000048c0| 69 73 20 68 61 73 20 6e | 6f 74 20 62 65 65 6e 20 |is has n|ot been |
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|000048e0| 20 65 66 66 65 63 74 73 | 20 6f 66 20 6f 72 61 6c | effects| of oral|
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|00004900| 74 72 61 74 69 6f 6e 20 | 6f 6e 20 65 78 65 72 63 |tration |on exerc|
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|00004920| 79 73 70 6e 65 61 2c 20 | 61 6e 64 20 61 72 74 65 |yspnea, |and arte|
|00004930| 72 69 61 6c 20 62 6c 6f | 6f 64 20 67 61 73 20 6c |rial blo|od gas l|
|00004940| 65 76 65 6c 73 0d 0a 77 | 65 72 65 20 61 73 73 65 |evels..w|ere asse|
|00004950| 73 73 65 64 20 69 6e 20 | 31 33 20 65 75 63 61 70 |ssed in |13 eucap|
|00004960| 6e 69 63 20 70 61 74 69 | 65 6e 74 73 20 61 67 65 |nic pati|ents age|
|00004970| 64 20 35 38 2d 37 30 20 | 79 65 61 72 73 20 77 69 |d 58-70 |years wi|
|00004980| 74 68 20 73 74 61 62 6c | 65 20 43 4f 50 44 2e 20 |th stabl|e COPD. |
|00004990| 20 54 68 65 0d 0a 70 61 | 74 69 65 6e 74 73 20 70 | The..pa|tients p|
|000049a0| 65 72 66 6f 72 6d 65 64 | 20 64 75 70 6c 69 63 61 |erformed| duplica|
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|00004a40| 20 62 6c 6f 6f 64 20 64 | 65 74 65 72 6d 69 6e 61 | blood d|etermina|
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|00004a60| 6f 66 20 61 63 74 69 76 | 65 20 6d 65 64 69 63 61 |of activ|e medica|
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|00004a90| 68 65 20 6d 6f 72 70 68 | 69 6e 65 20 73 6f 6c 75 |he morph|ine solu|
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|00004ab0| 61 78 69 6d 61 6c 20 77 | 6f 72 6b 6c 6f 61 64 0d |aximal w|orkload.|
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|00004ad0| 2e 36 25 20 66 72 6f 6d | 20 37 38 2e 35 20 74 6f |.6% from| 78.5 to|
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|00004af0| 20 6d 65 61 6e 20 64 75 | 72 61 74 69 6f 6e 20 6f | mean du|ration o|
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|00004b20| 6f 20 37 2e 35 20 6d 69 | 6e 75 74 65 73 2e 20 20 |o 7.5 mi|nutes. |
|00004b30| 54 68 65 20 6d 65 61 6e | 20 6f 78 79 67 65 6e 20 |The mean| oxygen |
|00004b40| 75 70 74 61 6b 65 20 69 | 6e 63 72 65 61 73 65 64 |uptake i|ncreased|
|00004b50| 20 62 79 20 31 39 2e 33 | 25 2c 0d 0a 61 6e 64 20 | by 19.3|%,..and |
|00004b60| 74 68 65 20 6d 65 61 6e | 20 63 61 72 62 6f 6e 20 |the mean| carbon |
|00004b70| 64 69 6f 78 69 64 65 20 | 6f 75 74 70 75 74 20 69 |dioxide |output i|
|00004b80| 6e 63 72 65 61 73 65 64 | 20 62 79 20 31 33 25 2e |ncreased| by 13%.|
|00004b90| 20 20 44 65 73 70 69 74 | 65 20 74 68 65 20 68 69 | Despit|e the hi|
|00004ba0| 67 68 65 72 0d 0a 76 65 | 6e 74 69 6c 61 74 69 6f |gher..ve|ntilatio|
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|00004be0| 6d 65 61 6e 20 42 6f 72 | 67 20 73 63 6f 72 65 20 |mean Bor|g score |
|00004bf0| 77 61 73 0d 0a 6e 6f 74 | 20 73 69 67 6e 69 66 69 |was..not| signifi|
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|00004c10| 20 20 20 20 20 54 68 65 | 20 69 6d 70 72 6f 76 65 | The| improve|
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|00004c40| 62 65 20 72 65 6c 61 74 | 65 64 20 74 6f 20 61 20 |be relat|ed to a |
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|00004c60| 20 63 61 72 62 6f 6e 20 | 64 69 6f 78 69 64 65 20 | carbon |dioxide |
|00004c70| 70 72 65 73 73 75 72 65 | 20 61 6e 64 20 61 20 72 |pressure| and a r|
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|00004cb0| 20 6c 65 76 65 6c 20 6f | 66 20 76 65 6e 74 69 6c | level o|f ventil|
|00004cc0| 61 74 69 6f 6e 2e 0d 0a | 0d 0a 50 6f 73 74 2d 43 |ation...|..Post-C|
|00004cd0| 6f 6d 6d 65 6e 74 0d 0a | 0d 0a 20 20 20 20 20 50 |omment..|.. P|
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|00004d00| 20 70 75 6c 6d 6f 6e 61 | 72 79 20 64 69 73 65 61 | pulmona|ry disea|
|00004d10| 73 65 20 67 6f 20 74 68 | 72 6f 75 67 68 20 6c 69 |se go th|rough li|
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|00004d50| 20 69 6d 70 61 69 72 65 | 64 20 62 79 20 62 72 65 | impaire|d by bre|
|00004d60| 61 74 68 6c 65 73 73 6e | 65 73 73 20 64 75 72 69 |athlessn|ess duri|
|00004d70| 6e 67 0d 0a 65 78 65 72 | 74 69 6f 6e 2c 20 64 65 |ng..exer|tion, de|
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|00004d90| 20 62 72 6f 6e 63 68 6f | 64 69 6c 61 74 6f 72 73 | broncho|dilators|
|00004da0| 2c 20 63 6f 72 74 69 63 | 6f 73 74 65 72 6f 69 64 |, cortic|osteroid|
|00004db0| 73 2c 20 72 65 68 61 62 | 69 6c 69 74 61 74 69 6f |s, rehab|ilitatio|
|00004dc0| 6e 0d 0a 74 72 61 69 6e | 69 6e 67 2c 20 61 6e 64 |n..train|ing, and|
|00004dd0| 20 6f 78 79 67 65 6e 20 | 74 68 65 72 61 70 79 2e | oxygen |therapy.|
|00004de0| 20 20 42 65 6e 7a 6f 64 | 69 61 7a 65 70 69 6e 65 | Benzod|iazepine|
|00004df0| 73 20 68 61 76 65 20 62 | 65 65 6e 20 64 69 73 61 |s have b|een disa|
|00004e00| 70 70 6f 69 6e 74 69 6e | 67 20 69 6e 20 74 68 69 |ppointin|g in thi|
|00004e10| 73 0d 0a 73 69 74 75 61 | 74 69 6f 6e 2c 20 62 75 |s..situa|tion, bu|
|00004e20| 74 20 6f 70 69 61 74 65 | 73 20 64 6f 20 73 65 65 |t opiate|s do see|
|00004e30| 6d 20 74 6f 20 69 6e 63 | 72 65 61 73 65 20 74 68 |m to inc|rease th|
|00004e40| 65 20 65 78 65 72 63 69 | 73 65 20 74 6f 6c 65 72 |e exerci|se toler|
|00004e50| 61 6e 63 65 20 6f 66 20 | 70 61 74 69 65 6e 74 73 |ance of |patients|
|00004e60| 0d 0a 77 69 74 68 20 43 | 4f 50 44 2e 20 20 59 65 |..with C|OPD. Ye|
|00004e70| 61 72 73 20 61 67 6f 20 | 49 20 77 61 73 20 61 20 |ars ago |I was a |
|00004e80| 76 6f 6c 75 6e 74 65 65 | 72 20 69 6e 20 61 20 73 |voluntee|r in a s|
|00004e90| 74 75 64 79 20 77 68 65 | 72 65 69 6e 20 49 20 68 |tudy whe|rein I h|
|00004ea0| 61 64 20 74 6f 20 62 72 | 65 61 74 68 20 35 25 0d |ad to br|eath 5%.|
|00004eb0| 0a 43 4f 32 20 62 65 66 | 6f 72 65 20 61 6e 64 20 |.CO2 bef|ore and |
|00004ec0| 61 66 74 65 72 20 6d 6f | 72 70 68 69 6e 65 2e 20 |after mo|rphine. |
|00004ed0| 20 54 68 65 20 66 6f 72 | 63 65 64 20 68 79 70 65 | The for|ced hype|
|00004ee0| 72 76 65 6e 74 69 6c 61 | 74 69 6f 6e 20 62 79 20 |rventila|tion by |
|00004ef0| 74 68 65 20 68 69 67 68 | 0d 0a 61 6c 76 65 6f 6c |the high|..alveol|
|00004f00| 61 72 20 70 43 4f 32 20 | 77 61 73 20 75 6e 70 6c |ar pCO2 |was unpl|
|00004f10| 65 61 73 61 6e 74 20 77 | 68 65 6e 20 49 20 77 61 |easant w|hen I wa|
|00004f20| 73 20 75 6e 6d 65 64 69 | 63 61 74 65 64 2c 20 62 |s unmedi|cated, b|
|00004f30| 75 74 20 71 75 69 74 65 | 20 74 6f 6c 65 72 61 62 |ut quite| tolerab|
|00004f40| 6c 65 20 61 66 74 65 72 | 0d 0a 6d 6f 72 70 68 69 |le after|..morphi|
|00004f50| 6e 65 2c 20 61 74 20 6c | 65 61 73 74 20 69 6e 20 |ne, at l|east in |
|00004f60| 70 61 72 74 20 62 65 63 | 61 75 73 65 20 74 68 65 |part bec|ause the|
|00004f70| 20 64 72 75 67 20 72 65 | 64 75 63 65 64 20 74 68 | drug re|duced th|
|00004f80| 65 20 76 65 6e 74 69 6c | 61 74 6f 72 79 20 64 72 |e ventil|atory dr|
|00004f90| 69 76 65 2e 0d 0a 20 20 | 20 20 20 4f 70 69 61 74 |ive... | Opiat|
|00004fa0| 65 73 20 77 65 72 65 20 | 75 73 65 64 20 66 6f 72 |es were |used for|
|00004fb0| 20 64 65 63 61 64 65 73 | 2c 20 73 74 61 72 74 69 | decades|, starti|
|00004fc0| 6e 67 20 69 6e 20 74 68 | 65 20 6c 61 74 65 20 31 |ng in th|e late 1|
|00004fd0| 39 74 68 20 63 65 6e 74 | 75 72 79 2c 20 74 6f 0d |9th cent|ury, to.|
|00004fe0| 0a 72 65 6c 69 65 76 65 | 20 62 72 65 61 74 68 6c |.relieve| breathl|
|00004ff0| 65 73 73 6e 65 73 73 2c | 20 62 75 74 20 66 65 6c |essness,| but fel|
|00005000| 6c 20 69 6e 74 6f 20 64 | 69 73 72 65 70 75 74 65 |l into d|isrepute|
|00005010| 20 61 62 6f 75 74 20 33 | 30 20 79 65 61 72 73 20 | about 3|0 years |
|00005020| 61 67 6f 2e 20 20 57 69 | 6c 6c 20 74 68 65 79 0d |ago. Wi|ll they.|
|00005030| 0a 63 6f 6d 65 20 62 61 | 63 6b 20 61 73 20 74 68 |.come ba|ck as th|
|00005040| 65 72 61 70 79 20 66 6f | 72 20 43 4f 50 44 20 62 |erapy fo|r COPD b|
|00005050| 72 65 61 74 68 6c 65 73 | 73 6e 65 73 73 3f 20 20 |reathles|sness? |
|00005060| 54 68 65 20 61 6e 73 77 | 65 72 20 77 69 6c 6c 20 |The answ|er will |
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|00005ef0| 41 6c 6c 65 72 67 79 7d | 0d 0a 24 56 6f 6c 75 6d |Allergy}|..$Volum|
|00005f00| 65 7b 36 31 7d 0d 0a 24 | 50 61 67 65 7b 31 34 37 |e{61}..$|Page{147|
|00005f10| 2d 31 35 30 7d 0d 0a 24 | 44 61 74 65 7b 41 75 67 |-150}..$|Date{Aug|
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|00005f30| 6c 7b 31 39 39 30 20 59 | 65 61 72 20 42 6f 6f 6b |l{1990 Y|ear Book|
|00005f40| 20 6f 66 20 44 72 75 67 | 20 54 68 65 72 61 70 79 | of Drug| Therapy|
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|00005f60| 7d 0d 0a 24 59 42 45 64 | 69 74 6f 72 7b 44 72 73 |}..$YBEd|itor{Drs|
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|00005f90| 7b 54 61 62 6c 65 20 4f | 6d 69 74 74 65 64 7d 0d |{Table O|mitted}.|
|00005fa0| 0a 24 43 6f 6d 6d 65 6e | 74 61 74 6f 72 7b 4c 2e |.$Commen|tator{L.|
|00005fb0| 45 2e 20 48 6f 6c 6c 69 | 73 74 65 72 2c 20 4d 2e |E. Holli|ster, M.|
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|00005ff0| 2c 20 49 6e 63 2e 2c 20 | 31 39 39 30 0d 0a 0d 0a |, Inc., |1990....|
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|00006110| 72 61 6e 69 20 46 4b 3b | 20 52 69 63 68 61 72 64 |rani FK;| Richard|
|00006120| 73 20 57 3b 20 43 68 75 | 72 63 68 20 4a 41 3b 20 |s W; Chu|rch JA; |
|00006130| 52 6f 62 65 72 74 73 20 | 4d 4a 3b 20 4b 65 65 6e |Roberts |MJ; Keen|
|00006140| 73 20 54 47 0d 0a 28 55 | 6e 69 76 20 6f 66 20 53 |s TG..(U|niv of S|
|00006150| 6f 75 74 68 65 72 6e 20 | 43 61 6c 69 66 6f 72 6e |outhern |Californ|
|00006160| 69 61 2c 20 4c 6f 73 20 | 41 6e 67 65 6c 65 73 29 |ia, Los |Angeles)|
|00006170| 0d 0a 41 6e 6e 20 41 6c | 6c 65 72 67 79 20 36 31 |..Ann Al|lergy 61|
|00006180| 3a 31 34 37 2d 31 35 30 | 2c 20 41 75 67 75 73 74 |:147-150|, August|
|00006190| 20 31 39 38 38 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d | 1988..-|--------|
|000061a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00006230| 20 62 79 20 74 69 64 61 | 6c 20 62 72 65 61 74 68 | by tida|l breath|
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+--------+-------------------------+-------------------------+--------+--------+
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